Toxicogenomics Challenges & Applications
Toxicogenomic data assist hazard identification and investigate causes. The key challenge is data interpretation, because toxicogenomics can find molecular changes that are causal, associated with or incidental to toxicity. Using microarrays, scientists can literally see which genes are triggered, repressed, or unchanged by a chemical.
- Gene annotation
- Cross-species extrapolation
- Biomarker qualification
- Translation of assays for regulatory purposes
- Toxicogenomics in regulatory application
- Role of toxicogenomics dose-response analysis
- Validation of biomarkers
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