Biomarkers in Toxicogenomics
In the area of toxicology, the subdiscipline of toxicogenomics has emerged, which is the use of genome-scale mRNA expression profiling to monitor responses to adverse xenobiotic exposure. Toxicogenomics is being investigated for use in the triage of compounds through predicting potential toxicity, defining mechanisms of toxicity, and identifying potential biomarkers of toxicity. Whereas various approaches have been reported for the development of algorithms predictive of toxicity and for the interpretation of gene expression data for deriving mechanisms of toxicity, there are no clearly defined methods for the discovery of biomarkers using gene expression technologies. Ways in which toxicogenomics may be used for biomarker discovery include analysis of large databases of gene expression profiles followed by in silico mining of the database for differentially expressed genes; the analysis of gene expression data from preclinical studies to find differentially expressed genes that correlate with pathology (coincident biomarker) or precede pathology (leading biomarker) within a lead series; or gene expression profiling can be performed directly on the blood from preclinical studies or clinical trials to find biomarkers that can be obtained noninvasively. This chapter broadly discusses the issues and the utility of applying toxicogenomics to biomarker discovery.
- Compliance guidance
- Systems toxicology
- Drug toxicology
Related Conference of Biomarkers in Toxicogenomics
19th World Congress on Tissue Engineering Regenerative Medicine and Stem Cell Research
17th International Conference on Human Genomics and Genomic Medicine
Biomarkers in Toxicogenomics Conference Speakers
Recommended Sessions
- Adverse Outcome Pathways
- Biomarkers in Toxicogenomics
- Cardiovascular Toxicology
- Concept of Toxicogenomics
- Drug monitoring
- Genetic Toxicology
- Genomic Approaches to Predictive Toxicology
- Predictive Human Toxicity and ADME/Tox Studies
- Reproductive and Developmental Toxicology
- Technologies in Toxicogenomics
- Toxicogenomics
- Toxicology study in Haemostasis
- Toxicopathology
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